02368cam a22004338a 4500 16780199 20150127133428.0 110512s2012 nyu b 001 0 eng 2011020446 9780071603935 (hardcover : alk. paper) 007160393X (hardcover : alk. paper) 9781259071409 (DNLM)101560548 DNLM/DLC DLC pcc RM 301.4 .Sh52 2012 QV 38 615/.7 Shargel, Leon, 1941- Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Andrew B.C. Yu, Susanna Wu-Pong. Applied biopharmaceutics and pharmacokinetics 6th ed. New York : McGraw-Hill, 2012. 1212 811 pages : 24 cm. illustrations ; Includes bibliographical references and index. Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease. Pharmacy Biopharmaceutics. Pharmacokinetics. Biopharmaceutics. Models, Chemical. Pharmacokinetics. Yu, Andrew B. C., 1945- Wu-Pong, Susanna. 7 cbc orignew 1 ecip 20 y-gencatlg lcc BK 278743 278743 0 0 lcc 0 SSLC SSLC SSLC 2015-01-27 Library Fund SSLC 4 8 RM 301.4 .Sh52 2012 SSLC1393 2019-09-03 00:00:00 2019-07-11 2015-01-27 BK