Applied biopharmaceutics & pharmacokinetics /
Shargel, Leon, 1941- ,
Applied biopharmaceutics & pharmacokinetics / Applied biopharmaceutics and pharmacokinetics Leon Shargel, Andrew B.C. Yu. - 7th edition. - New York : McGraw Hill, 2016. - xvii, 910 pages : 24 cm. illustrations ;
Includes bibliographical references and index.
Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis.
9780071830935 (hardcover : alk. paper) 0071830936 (hardcover : alk. paper)
2015014810
Biopharmaceutics.
Pharmacokinetics.
Drug Administration Routes.
Models, Chemical.
RM 301.4 / .Sh531 2016
615.7
QV 38
Applied biopharmaceutics & pharmacokinetics / Applied biopharmaceutics and pharmacokinetics Leon Shargel, Andrew B.C. Yu. - 7th edition. - New York : McGraw Hill, 2016. - xvii, 910 pages : 24 cm. illustrations ;
Includes bibliographical references and index.
Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis.
9780071830935 (hardcover : alk. paper) 0071830936 (hardcover : alk. paper)
2015014810
Biopharmaceutics.
Pharmacokinetics.
Drug Administration Routes.
Models, Chemical.
RM 301.4 / .Sh531 2016
615.7
QV 38